22year old male with DRUG INDUCED CUSHINGS with suppressed HPA axis with dengue

 


 This is an online E log book to discuss our patient's de-identified health data shared after taking his/her/guardian's signed informed consent. Here we discuss our individual patient's problems through series of inputs from global online community of experts with an aim to solve those patient's clinical problems with collective current best evidence based inputs. This E log book also reflects my patient-centred online learning portfolio and your valuable inputs on the comment box is welcome."I've been given this case to solve in an attempt to understand the topic of "patient clinical data analysis" to develop my competency in reading and comprehending clinical data including history, clinical findings, investigations and come up with a diagnosis and treatment plan.

A 22 year old male , who is a known case of CUSHING’s SYNDROME (drug induced) with suppressed HPA axis on hydrocortisone came to the casualty  with COMPLAINTS OF: 

Fever since 3 days 

Vomitings since 2days 

Joint pains and headache since yesterday. 

Patient was apparently asymptomatic way back in 2019, then he developed red itchy ring like lesion over the thigh for which he applied CLOBETA-GM For 7 months … intermittently he also took RAKTHA SODHINI SYRUP (Ayurvedic pathanjali ) 400 ml in October 2019 . 

His lesions increased and blood was oozing from then and he also noticed that he was gaining weight ( 50kgs to 70kgs) . 

He went to other centre in October and was diagnosed with TINEA INCOGNITO for which he was prescribed XYZAL TABLETS AND EBERNET CREAM AND SEBIFIN CREAM.

Patient had fever after 5 days of using creams and anti fungals which was high grade and associated with chills and rigors and joint pains for which he was prescribed antoxid cefixime for 1 week. 

At a review after 1 month for his allergy , during a follow up in December , patient gives H/O ORAL STEROID INTAKE ( HYSONE 5mg) for 6 months [ 1 -1/2-1/2 ] prescribed by endocrinologist, and was also prescribed antifungals itraconazole and ketoconazole . 

The patient’s last visit to our hospital was back in October 2021 , when he came for ACTH STIMULATION TEST. ( to know 8 am CORTISOL LEVELS ) 

RESULTS OF PREVIOUS ACTH STIMULATION TESTS: 

20th March 2020 - 11.34 microgram / DL 

18th august 2020 - 10.7 micro gram /DL 

28TH FEB 2021 - 8.9 MICROGRAM/ DL 

Patient has been on tab. HISONE {AFTER BEING DIAGNOSED WITH IATROGENIC CUSHINGS AND ADRENAL INSUFFICIENCY } which was then tapered after getting regular serum cortisol tests. 


Patient was started on HISONE (10mg-5mg-5mg) which was then tapered to HISONE (5mg-2.5mg-2.5mg) 6 months ago : 


 

                  6am   12pm   4pm    

HISONE -  10mg   5mg    5mg    } 

                                  tapered to   { 6months ago } 

HISONE - 5mg     2.5mg 2.5mg


Today as on: 20/3/2021 he complains of fever ,vomitings (2episodes,non blood stained)  headache and joint pains since 3 days . Tests done outside I/v/o the above complaint : dengue NS1 -positive 
                    Dengue IgM - positive 
PAST HISTORY: not a known case of tuberculosis, epilepsy,asthma 
Diagnosed with diabetes mellitus (steroid  Induced)

GENERAL EXAMINATION:
On examination : patient is conscious and coherent 
CVS : s1s2+ 
RS: BAE+ 
VITALS : BP: 120/70 mmhg 
                  PR: 90 bpm 
                 Temp : 99.4 degrees F 
                  SPO2: 100% @ R.A 
                  GRBS : 213mg / DL 
ABDOMEN: soft , non tender , mildly distended 
                      With evident STRIAE 
CNS : NAD 


PROVISIONAL DIAGNOSIS; 
K/C/O STEROID INDUCED CUSHING SYNDROME WITH SUPPRESSED HPA AXIS , with FEVER UNDER EVALUATION. ?viral pyrexia ? Dengue ?steroid induced diabetes mellitus 

INVESTIGATIONS:


















TREATMENT:
1) IVF NS @ 100ml/hr 
2) Inj.ZOFER4mg IV / STAT 
3) Inj. PAN 40mg IV / STAT 
4) Tab. Dolo 650 mg PO/TID 
5) INJ. Neomol 1gm IV / SOS ( > 101 degrees F) 
6) Inj. OPTINEURON  1 amp in 100ml NS 
7) TAB. HISONE- 5mg -2.5mg-2.5mg 


8) temp charting , BP , PR MONITORING 
9) GRBS - 6th HOURLY 


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